Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice.
نویسندگان
چکیده
This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.
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ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 71 4 شماره
صفحات -
تاریخ انتشار 2007